Beautiful Chemistry: Hoye's HDDA + Napth Trap

Every so often, a reaction behaves so well that you just publish the crude  NMR spectrum. Professor Tom Hoye's HDDA* reaction, first rep...

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Honing Halophilicity

Let's say you have a late-stage drug candidate, with an alcohol, an olefin, and a pyridine. Now you toss in one equivalent of a chlorina...

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Tip of the Iceberg: More Organic Letters Corrections

( Thanks to BRSM for the heads up!) (Update :  See here for Derek's post and thoughts ) Looks like another author just felt the heat of...

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A Soapy Situation

Life has funny ways of surprising you. While analyzing my latest batch of a functionalized sugar, I noticed that the NMR sample foamed upon ...

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Start-up, Year Two

As my tiny company hovers on the brink of non-existence, I recently passed my second-year employment anniversary. Here's how the numbers...

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JFK Scare: Analytical Chemistry at the Airport

Please see below for updates as I receive further information... As reported by multiple news outlets ( CNN , Daily Mail , The Atlantic ), a...

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Pyramid Power!

Atop the energy barrier between hardcore synthetic jocks and dyed-in-the-wool physical chemists lives a dedicated group: the molecular archi...

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Molecular Machine, Unadorned

So, chemists, you've probably seen this article over at Nature News, which reports a "molecular robot" capable of traveling d...

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